Patricia A. Hunt and Terry J. Hassold, Human female meiosis: what makes a good egg go bad, Trends in GeneticsVolume 24, Issue 2 , February 2008, Pages 86-93.
Terry Hassold , Heather Hall , and Patricia Hunt The origin of human aneuploidy: where we have been, where we are going Hum. Mol. Genet. 2007 Oct 15;16(R2):R203-208
Heather E. Hall, E. Ricky Chan, Andrew Collins, LuAnn Judis, Sofia Shirley, Urvashi Surti, Lori Hoffner, Annette E. Cockwell , Patricia A. Jacobs , Terry J. Hassold. The origin of trisomy 13. Am J Med Genet A. 2007 Oct 1;143(19):2242-8.
Heather E. Hall, Urvashi Surti, Lori Hoffner, Sofia Shirley, Eleanor Feingold, Terry Hassold. The origin of trisomy 22: evidence for acrocentric chromosome-specific patterns of nondisjunction. Am J Med Genet A. 2007 Oct 1;143(19):2249-55
Terry Hassold & Patricia Hunt. Rescuing distal crossovers. Nature Genetics 39, 1187 - 1188 (2007)
doi:10.1038/ng1007-1187
Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol 2007 Aug-Sep;24(2):131-8. Epub 2007 Jul 27
Ruth A. Keri, Shuk-Mei Ho, Patricia A. Hunt, Karen E. Knudsen, Ana M. Soto and Gail S. Prins, An evaluation of evidence for the carcinogenic activity of bisphenol A, Reproductive ToxicologyVolume 24, Issue 2, , August-September 2007, Pages 240-252.
Mark T. Johnson, Edward A. Freeman, David K. Gardner, and Patricia A. Hunt. Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo. Biol Reprod. 2007 Jul;77(1):2-8. Epub 2007 Feb 21.
S. Cherry, C. Adelman, J. Theunissen, T. Hassold, P. Hunt, J. Petrini The Mre11 Complex Influences DNA Repair, Synapsis, and Crossing Over in Murine Meiosis. Curr Biol. 2007 Feb 20;17(4):373-8. Epub 2007 Feb 8.
Martha Susiarjo, Terry J Hassold, Edward Freeman, and Patricia A Hunt. Bisphenol A exposure in utero disrupts early oogenesis in the mouse. PLoS Genet. 2007 Jan 12;3(1):e5.
Daniel Topping, Petrice Brown, LuAnn Judis, Stuart Schwartz, Allen Seftel, Anthony Thomas and Terry Hassold. Synaptic defects at meiosis I and non-obstructive azoospermia. Hum Reprod. 2006 Dec;21(12):3171-7. Epub 2006 Jul 22
Rhea U. Vallente, Edith Y. Cheng and Terry J. HassoldThe synaptonemal complex and meiotic recombination in humans: new approaches to old questions. Chromosoma. 2006 Jun;115(3):241-9. Epub 2006 Mar 18. Review.
K. Koehler, S. Schrump, J. Cherry, T. Hassold, P. Hunt Near-human aneuploidy levels in female mice with homeologous chromosomes. Curr Biol. 2006 Aug 8;16(15):R579-80.
Heather Hall, Patricia Hunt and Terry Hassold. Meiosis and sex chromosome aneuploidy: how meiotic errors cause aneuploidy; how aneuploidy causes meiotic errors. Curr Opin Genet Dev. 2006 Jun;16(3):323-9. Epub 2006 May 2. Review.
Craig A Hodges Ekaterina Revenkova Rolf Jessberger Terry J Hassold & Patricia A Hunt. SMC1β-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction. Nature Genetics 37, 1351 - 1355 (2005).
Audrey Lynn, Stefanie Schrump, Jonathan Cherry, Terry Hassold, and Patricia Hunt. Sex, not genotype, determines recombination levels in mice. Am J Hum Genet. 2005 Oct;77(4):670-5. Epub 2005 Aug 17.
Mann MB, Hodges CA, Barnes E, Vogel H, Hassold TJ, Luo G. Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome. Hum Mol Genet. 2005 Mar 15;14(6):813-25.
Cherry SM, Hunt PA, Hassold TJ. Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation. Mutat Res. 2004 Dec 12;564(2):115-28.
Hassold T, Judis L, Chan ER, Schwartz S, Seftel A, Lynn A. Cytological studies of meiotic recombination in human males. Cytogenet Genome Res. 2004;107(3-4):249-55.
Koehler KE, Millie EA, Cherry JP, Schrump SE, Hassold TJ. Meiotic exchange and segregation in female mice heterozygous for paracentric inversions. Genetics. 2004 Mar;166(3):1199-214.
Judis L, Chan ER, Schwartz S, Seftel A, Hassold T. Meiosis I arrest and azoospermia in an infertile male explained by failure of formation of a component of the synaptonemal complex. Fertil Steril. 2004 Jan;81(1):205-9.
Revenkova E, Eijpe M, Heyting C, Hodges CA, Hunt PA, Liebe B, Scherthan H, Jessberger R. Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination. Nat Cell Biol. 2004 Jun;6(6):555-62.
Lynn A, Ashley T, Hassold T. Variation in human meiotic recombination. Annu Rev Genomics Hum Genet. 2004;5:317-49.
Lamb NE, Hassold TJ. Nondisjunction--a view from ringside. N Engl J Med. 2004 Nov 4;351(19):1931-4.
Thomas NS, Hassold TJ. Aberrant recombination and the origin of Klinefelter syndrome. Hum Reprod Update. 2003 Jul-Aug;9(4):309-17.
Theunissen JW, Kaplan MI, Hunt PA, Williams BR, Ferguson DO, Alt FW, Petrini JH. Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell. 2003 Dec;12(6):1511-23.
Hunt PA, Koehler KE, Susiarjo M, Hodges CA, Ilagan A, Voigt RC, Thomas S, Thomas BF, Hassold TJ. Bisphenol a exposure causes meiotic aneuploidy in the female mouse. Curr Biol. 2003 Apr 1;13(7):546-53.
Hunt PA, Koehler KE, Susiarjo M, Hodges CA, Ilagan A, Voigt RC, Thomas S, Thomas BF, Hassold TJ. Bisphenol a exposure causes meiotic aneuploidy in the female mouse. Curr Biol: 13(7):546-53, 2003.
Thomas NS, Hassold TJ. Aberrant recombination and the origin of Klinefelter syndrome. Hum Reprod Update: 9(4):309-17, 2003 .
Lynn A, Koehler KE, Judis L, Chan ER, Cherry JP, Schwartz S, Seftel A, Hunt PA, Hassold TJ. Covariation of synaptonemal complex length and mammalian meiotic exchange rates. Science:296(5576):2222-5, 2002.
Bean CJ, Hassold TJ, Judis L, Hunt PA. Fertilization in vitro increases non-disjunction during early cleavage divisions in a mouse model system. Hum Reprod: 17(9):2362-7, 2002.
Koehler KE, Cherry JP, Lynn A, Hunt PA, Hassold TJ. Genetic control of mammalian meiotic recombination. I. Variation in exchange frequencies among males from inbred mouse strains. Genetics:162(1):297-306, 2002.
Hodges, C.A., Ilagan, A., Jennings, D., Keri, R., Nilson, J., Hunt, P.A., Experimental evidence that changes in oocyte growth influence meiotic chromosome segregation, Human Reproduction, 17:1171-1180, 2002.
Koehler KE, Millie EA, Cherry JP, Burgoyne PS, Evans EP, Hunt PA, Hassold TJ. Sex-specific differences in meiotic chromosome segregation revealed by dicentric bridge resolution in mice. Genetics: 162(3):1367-79, 2002.
Hunt PA, Hassold TJ. Sex matters in meiosis. Science: 296(5576):2181-3, 2002
Thomas S, Ennis S, Sharp A, Durkie M, Hassold T, Collins A, Jacobs P. Maternal sex chromosome non-disjunction: evidence for X chromosome-specific risk factors. Hum Molec Genet 10: 243-250, 2001.
Hodges, C.A., LeMaire-Adkins, R., Hunt, P.A., The control of meiotic chromosome segregation: Evidence for sexual dimorphism in the meiotic chromosome cohesion complex, Journal of Cell Science, 114:2417-2426, 2001.
Bean C, Hunt P, Millie E, Hassold T. Analysis of a malsegregating mouse Y chromosome: evidence that the earliest cleavage divisions of the mammalian embryo are nondisjunction-prone. Hum Molec Genet 10: 963-972, 2001.
Hassold T, Burrage L, Chan E, Judis L, James S, Jacobs P, Thomas N. Maternal folate polymorphisms and the etiology of human nondisjunction. Am J Hum Genet 69: 434-439, 2001.
Hassold T, Schwartz S. Human chromosomes and chromosome disorders. In: Harrison's Principles of Internal Medicine Eds. E Braunwald, A Fauci, D Kasper, S Hauser, D Longo, J Jameson. McGraw-Hill, New York, NY pp 397-404, 2001.
Hassold T, Hunt P. To err (meiotically) is human: studies of the genesis of human aneuploidy. Nat Rev Genet 2: 280-291, 2001.
Hassold T, Sherman S. Down syndrome: genetic recombination and the origin of the extra chromosome 21. Clin Genet 57: 95-100, 2000.
Hassold T, Sherman S, Hunt P. Counting cross-overs: characterizing meiotic recombination in mammals. Hum Molec Genet 9: 2409-2419, 2000.
Zaragoza M, Surti U, Redline R, Millie E, Chakravarti A, Hassold T. Parental origin and phenotype of triploidy in spontaneous abortions: predominance of diandry and its association with the partial hydatidiform mole. Am J Hum Genet 66: 1807-1820, 2000.
Hixon M, Muro-Cacho C, Wagner M, Obejero-Paz C, Millie E, Fujio Y, Kureishi Y, Hassold T, Walsh K, Gualberto A. Akt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization. J Clin Invest 106: 1011-1120, 2000.
Lepage D, Church D, Millie E, Hassold T, Conlon R. Rapid generation of nested deletions on mouse chromosome 2. PNAS 97: 10471-10476, 2000.
Thomas S, Collins A Scambler P, Hassold T, Jacobs P. A reinvestigation of nondisjunction resulting in 47, XXY males of paternal origin. Eur J Hum Genet 8: 805-808, 2000.
Lemaire-Adkins, R. and Hunt, P.A., Nonrandom Segregation of the Mouse Univalent X Chromosome: Evidence of Spindle-mediated Meiotic Drive, Genetics, 156: 775-783, 2000.
Robinson W, Christian S, Kuchinka B, Schuffenhauser S, Malcolm S, Schinzel A, Hassold T, Ledbetter D. Somatic segregation errors predominantly contribute to the gain or loss of a paternal chromosome leading to uniparental disomy for chromosome 15. Clin Genet 57: 349-358, 2000.
Hixon M, Obejero-Paz C, Muro-Cacho C, Wagner M, Millie E, Nagy J, Hassold T, Gualberto A. Cks1 mediates vascular smooth muscle cell polyploidization. J Biol Chem 275: 40432-40442, 2000.
Redline R, Zaragoza M, Hassold T. Prevalence of developmental and inflammatory lesions in nonmolar first-trimester spontaneous abortions. Hum Pathol 30: 93-100, 1999.
Padungtod C, Xu H, Hassold T, Millie E, Ryan L, Savitz D, Christiani D, Xu X. Sperm aneuploidy among Chinese pesticide factory workers: scoring by the FISH method. Am J Industr Med 89: 1-9, 1999.
Shield JP, Wadsworth EJ, Hassold TJ, Judis LA, Jacobs PA. Is disomic homozygosity at the APECED locus the cause of increased autoimmunity in Down's syndrome? Arch Dis Child: 81(2):147-50, 1999 .
Mroz, K., Hassold, T., Hunt, P.A., Meiotic aneuploidy in the XXY mouse: Evidence that a compromised testicular environment increases the incidence of meiotic errors, Human Reproduction, 14:1151-1156, 1999.
Yang Q, Sherman S, Hassold T, Allran K, Taft L, Pettay D, Khoury M, Erickson D, Freeman S. Risk factors for trisomy 21: Maternal cigarette smoking and oral contraceptive use in a population-based case-control study. Genet in Med 1: 80-88, 1999.
Woods, L.M, Hodges, C.A., Baart E., Baker, S.M., Liskay, M., Hunt, P.A., Chromosomal influence on meiotic spindle assembly: Abnormal meiosis I in female Mlh1 mutant mice, Journal of Cell Biology, 145: 1-12, 1999.
Mroz, K., Carrel, L., Hunt, P.A., Germ cell development in the XXY mouse: Evidence that X chromosome reactivation is independent of sexual differentiation, Developmental Biology 207:229-238, 1999.
Redline R, Hassold T, Zaragoza M. Prevalence of the partial molar phenotype in triploidy of maternal and paternal origin. Hum Pathol 29: 505-511, 1998.
Hunt, P.A., Worthman, C., Levinson, H., Stallings, J., LeMaire, R., Mroz, K., Park, C., Handel MA: Germ cell loss in the XXY male mouse: Altered X-chromosome dosage affects prenatal development, Molecular Reproduction and Development. 49:101-111, 1998.
Shen J, Sherman S, Hassold T. Centromeric genotyping and direct analysis of nondisjunction in humans: Down syndrome. Chromosoma 107: 166-172, 1998.
Robinson W, Kuchinka B, Bernasconi F, Brondum-Nielsen K, Christian S, Horsthemke B, Langlois S, Ledbetter D, Michaelis R, Petersen M, Schinzel A, Schuffenhauer S, Schulze A, Hassold T. Maternal meiosis I nondisjunction of chromosome 15: dependence of the maternal age effect on level of recombination. Hum Molec Genet 7: 1011-1020, 1998.
Savage A, Petersen M, Pettay D, Taft L, Allran K, Freeman S, Karadima G, Avramopolous D, Torfs C, Mikkelsen M, Hassold T, Sherman S. Elucidating the mechanisms of paternal nondisjunction of chromosome 21 in humans. Hum Molec Genet 7: 1221-1227, 1998
Hixon M, Millie E, Judis L, Freeman S, Sherman S, Hassold T. FISH sperm studies of fathers of paternally-derived cases of trisomy 21: no evidence for an increase in aneuploidy. Hum Genet 103: 654-657, 1998.
Volarcik, K., Sheean, L., Goldfarb, J., Woods, L., Abdul-Karim, F., Hunt P.A., The meiotic competence of human oocytes is influenced by donor age: evidence that folliculogenesis is compromised in the reproductively aged ovary, Human Reproduction 13:154-160, 1998.
Zaragoza M, Millie E, Redline R, Hassold T. Studies of nondisjunction in trisomies 2, 7, 15, and 22: does the parental origin of trisomy influence placental morphology? J Med Genet 35: 924-931, 1998.
Freeman S, Taft L, Dooley K, Sherman S, Hassold T, Khour M, Saker D. A population-based study of congenital heart defects in Down syndrome. Am J Med Genet 80: 213-217, 1998.
Shaffer L, McCaskill C, Adkins K, Hassold T. A systematic search for uniparental disomy in early fetal losses: the results and a review of the literature. Am J Med Genet 79: 366-372, 1998.
Mroz K, Hassold T, Hunt P. Meiotic aneuploidy in a mouse model of Klinefelter syndrome. Hum Reprod 14: 1151-1156, 1998.
Redline R, Hassold T, Zaragoza M. Determinants of trophoblast hyperplasia in spontaneous abortions. Modern Path: 11: 1162-1168, 1998.
Koehler KE, Hassold TJ. Human aneuploidy: lessons from achiasmate segregation in Drosophila melanogaster. Ann Hum Genet: 62(6):467-479, 1998.
Hunt, P.A., The control of mammalian female meiosis: Factors that influence chromosome segregation, Journal of Assisted Reproduction and Genetics 15(5):246-252, 1998.
Koehler K, Hassold T. Human aneuploidy: lessons from achiasmate segregation in Drosophila melanogaster. Ann Hum Genet 62: 467-479, 1998.
Hunt, P. A. and LeMaire-Adkins, R., Genetic control of mammalian female meiosis, Current Topics in Developmental Biology , Handel, M.A. (ed) 37:359-381, 1998.
LeMaire-Adkins, R., Radke, K., Hunt, P.A., Lack of checkpoint control at the metaphase-anaphase transition: a mechanism of meiotic non-disjunction in mammalian females, Journal of Cell Biology 139:1611-1619, 1997.
Dr. Pat Hunt
Research Focus
Heading using the h3tag
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